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However, there was a significant reduction in the number of NCCs in the non-coronary leaflet of the aortic valve in mutants compared with controls (P < 0.005; Figure 3 M), suggesting that reduced contributions to this leaflet specifically might be relevant to abnormalities in valve leaflet patterning.
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The goal of the protein measurements was to assess potential perturbations in pathways known or predicted to be relevant to learning/memory and other neurological abnormalities seen in DS or mouse models of DS.
These results, together with the DNA repair function of HMGB1 (Figs 4 and 5, Supplementary Fig S4), might be relevant to the mitochondrial membrane potential abnormality (Fig 3A and B).
These angiogenic abnormalities may be relevant to the association between cancer and diabetes.
These abnormalities may be relevant to the aberrant immune homeostasis and the increased susceptibility to infections described in lupus.
These abnormalities may be relevant to the known increased risk of acute non-lymphocytic leukaemias in this group of patients and are likely to render the BM less able to withstand subsequent insults such as further chemotherapy or infection.
We have previously reported that, as in HLH, NK function is profoundly depressed in the vast majority of patients with MAS [ 17] suggesting that this immunologic abnormality might be relevant to the pathogenesis of the syndrome.
We have previously reported that, as in HLH, patients with MAS have profoundly decreased NK activity, suggesting that this abnormality might be relevant to the pathogenesis of the syndrome.
Other findings may be anomalies of a benign nature which have no relevance clinically and some abnormalities seen may not be relevant to the clinical problem being investigated but are important to note.
In conclusion, our results demonstrate that deficiency of FUS/TLS leads to behavioral and pathological abnormalities that might be relevant to neuropsychiatric or neurodegenerative disorders, including FTLD.
From a clinical perspective, aberrant use of a particular CD36 promoter could be a factor in metabolic abnormalities and might be relevant to disease mechanisms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com