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Thus, hCNT1 fits the profile of a transceptor and is likely to be relevant in tumor biology.
Although TGFβ does not appear to directly participate in enhancing CD248 expression during late tumorigenesis, loss of its ability to suppress CD248 may be relevant in tumor progression and metastasis.
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Evidence that the classical trade-off observed in microbial experimental populations - that a high mutation rate facilitates rapid adaptation but at the cost of increased mutational load - can also be relevant in tumors is based on findings on chromosomal instability.
ROS-sensitive proteins regulate a variety of cellular functions that are relevant in tumor onset and development.
Radiosensitization of sarcomas is relevant in tumors that exceed the size for therapeutic effectiveness of surgery or radiotherapy as a sole treatment [ 25- 27].
The microenvironment and receptor signaling of the tumor plays a role in promoting the expression of genes that may be relevant in promoting tumor metastases.
In conclusion, in cancer cells glycolysis with its related pathways appears to have a master feed-forward control over glutamine utilization pathway, a condition that may be relevant in sustaining tumor forming ability ' in vivo'.
Thus, alterations in the crosstalk between Aurora kinase A and p53 could be relevant in thyroid tumor progression by compromising the fidelity of chromosome segregation (Parry et al. 1998, Shahedian et al. 2001).
Our results suggest that THOC1 could be relevant in ovarian tumors, in which THOC1 expression levels were high in almost all the carcinomas analyzed.
Taken as a whole, inhibition of IL-10 signaling in macrophages may be beneficial in not only preventing aberrant angiogenesis in the eye, but may also be relevant in the prevention of tumor-infiltrating macrophages from becoming pro-angiogenic TAMs that have been implicated in tumor progression and metastasis.
MAP3K1 variants were found to be relevant in ER+ and PR+ tumors to greater degree than in ER negative or PR negative tumors [ 40].
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