The HSP90 co-chaperone cdc37 ranked the highest in a genome-wide functional screen on two KIT-mutant cell lines, suggesting that the chaperones are relevant in maintaining KIT signaling [ 68].
Suchman also distinguishes between gaining, maintaining or repairing legitimacy, and suggests that different legitimating strategies are relevant in these different situations.
TGF-β and BMPs, that are members of the TGF-β superfamily, also initiate pathways that are highly relevant in maintaining stem cell self-renewal [42], [88].
Furthermore, recent studies have shown that some sHSPs localize to the mammalian and plant ER, in which sHSPs would play protective effects, being indeed relevant in maintaining ER homeostasis [ 134].
Compatible with hypotheses that enhancement of 5-HT transmission is relevant to maintaining remission in MDD, about one-half of remitted MDD subjects who are unmedicated or are being treated with SSRI agents experience depressive relapse under tryptophan depletion (which putatively decreases central serotonergic function; e.g., Neumeister et al. (2004).
For example, hGDAsBMP express higher levels of such astrocyte-related genes as glutamate transporter 1, connexin 43, and AKAP12, which are relevant to maintaining tissue homeostasis in the CNS as well as reducing astrogliosis and neuronal death after injury, mediating glutamate uptake and promoting blood-brain barrier formation [23], [24], [58] [61].
