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Influenza A virus (H3N2) infection of undifferentiated human bronchial epithelial cells NCI-H292 leads to induction of RANTES, IL-6 and IL-8 secretions, but not granulocyte-macrophage colony stimulating factor; these may be relevant in host defense and pathogenesis [27], [28].
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Some transcripts specifically modified by both EVs and tsRNAThr were reported to be relevant in host-parasite biology.
As some of the chemokines from our multiplex screening are relevant in host immune cell recruitment, we next tested the chemoattractive potential of supernatants from C. albicans-infected mast cells towards neutrophils and monocytes.
We identified an inhibitor that appears to inhibit three DUSPs, two of which are relevant in host responses to bacterial infections.
In the case of (Z -3-hexenyl acetate, the detected signal might also be relevant in long-range host location and host choice.
Particularly MMP-2 and -9 (so-called gelatinases A and B) seem to be relevant in extracellular remodeling and even pulmonary host defense.
Despite similar clinical outcomes, differences in the host transcriptional response could suggest that therapeutic targets identified in one host may not be relevant in another.
Interestingly, gut microbiota have been suggested to be relevant in B. thuringiensis infections in lepidopteran hosts [ 38– 40].
Further studies to test the stability/variability and fitness of particular plasmids among different bacterial hosts will be relevant in developing additional strategies to control dissemination of antimicrobial drug resistance.
This will be relevant in this story.
Such effects may be relevant in T1D.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com