Consistent with this observation, previous data in the literature indicate that the brain inflammatory response is relevant for stem cell survival and action [3], [8], [32].Our data also show other aspects of the complex interaction between NC and microglia/macrophages that appear to be engaged in a close physical reciprocal contact.
Neurosphere cultures are supposed to provide some of these niche signals that may be relevant for neural stem cell maintenance, survival and proliferation.
These findings could be relevant for the evolution of stem and progenitor cell dysfunction and the selective survival of aberrant and mutant stem and progenitor cell clones in conditions associated with DNA damage accumulation such as aging and carcinogenesis.
This knowledge will also be relevant for disease modeling from stem cells, or for regenerative strategies, since knowing whether a progenitor cell is committed to become a right ventricular cardiomyocyte vs an atrial cardiomyocyte, for example, could be critical depending upon the anatomic or cellular defect one is attempting to correct.
This observation could be relevant for the selection of stem cell donors for high risk AML patients who might benefit from GvL mediated by T cells alloreactive to non-permissive DPB1 TCE mismatches, in particular if in correlation with allelic HLA-DPA1 disparity.
This mechanism does not appear to be relevant for HEC activity in shoot stem cells, illustrating an exquisite spatial specificity.
The finding from this study showing that that telomerase expression ameliorates AIS could therefore be relevant for aneuploidy-induced transformation of stem and progenitor cells.
Density-dependent transition rates might be relevant for in vitro cultures of embryonic stem cells, which are known to differentiate when cell density becomes too large [ 8].
Adult models of psychopathology may not be relevant for childhood diagnoses; however, many adult problems stem from childhood disorders, and many childhood disorders have lifelong consequences.
Such translations may be relevant for addressing bone-to-bone impingements since the position of the stem in the femoral canal may influence this.
