Upon platelet activation, ADP is released to activate nearby platelets via the P2Y receptors.
Once lysosomes are ruptured by ROS, cathepsin B or L are released to activate caspases, which in turn inactivates proteins that protect cells from apoptosis (de Castro et al. 2016).
As BAK interacts with MCL-1 under normal condition and is released to be activated upon cell death stimuli, we examined the interaction of BAK with MCL-1 after GX15-070 treatment.
In our model, we could add matrix bound factors to the ECM, such as certain VEGF isoforms, which can be released or activated by MMPs.
The Giants have 21 days to determine whether Dixon will be released, activated or placed on a reserve list, keeping him out for the remainder of the season.... CORNELIUS GRIFFIN, the Giants' starting left defensive tackle, who is hobbled by an ankle sprain sustained Sunday in Minnesota, is listed as only 50-50 to face the Jets.
Tat is not only expressed in astrocytes and other productively infected cells like microglia, but it can also be released from these cells to activate other neighboring cells.
Beclin 1 interacts with Bcl-2 via the BH3 domain in Beclin 1 but can be released in starvation conditions to activate autophagy.
The model takes into account the dissociation of enoxaparin after any of these targets is bound to activated AT, and enoxaparin is released, allowing it to activate another molecule of AT.
The initial JAZ repressor that is released from MYC2 to activate transcription of target genes is JAZ3 [ 36, 47].
Both ligands are secreted into the perivitelline space and transported towards the dorsal midline [ 17, 20- 24], where BMP-ligand dimers are released from antagonists to activate a receptor complex and initiate intracellular signaling [ 17, 20, 25- 27].
