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NGAL is known to be released by activated neutrophils and appears to be elevated in sepsis, which may complicate its diagnostic value for AKI in patients with sepsis.
First, we stimulated immortalized and primary keratinocytes with different concentrations of chitin fragments and analyzed whether keratinocytes responded with secretion of a prototypical innate immune chemokine, CXCL8 (IL-8), known to be released by activated keratinocytes and recruiting neutrophils to the site of infection.
PDGF can also be released by activated macrophages [ 6].
Under asthmatic conditions, ECP would be released by activated eosinophils and damage bronchial epithelial cells.
During systemic inflammation, ATP may be released by activated platelets and leukocytes.
VEGF is known to be released by activated mast cells and has a rapid effect on endothelial cells.
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In this context, the present study confirms that active caspase-1 is released by activated monocytes in microparticles less than 0.1 µm and that this encapsulation is critical for its apoptotic function.
The second group, the platelet-derived microparticles (PMPs) are released by activated platelets [ 21] and are able to activate platelets and endothelial cells [ 22], monocyte adhesion [ 23] and the release of inflammatory cytokines [ 24] and induce endothelial apoptosis [ 25].
As VEGF is released by activated platelets (7– 10), as occurs in serum samples, platelet activation during blood collection could be an artificial source of VEGF in plasma samples as well, but this possibility was not explored in the studies mentioned (19, 23, 24).
RANKL is released by activated T-cells and binds RANK on osteoclastic precursors and thereby induce and activate osteoclasts [ 17].
Under normal circumstances, unusually large multimers (UL) of von Willebrand factor (VWF) are released by activated endothelial cells and subsequently rapidly proteolysed by ADAMTS-13 into smaller, less active forms.
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