To understand how individual mutations are spatially related to functionally conserved regions in CK1ε, we developed three-dimensional models for individual CK1ε mutants.
Other loci identified in this study were found to be related functionally to HNF4A and also include ATG5 and TADA3L, which may have roles in mediating susceptibility to later disease.
Since the cerebellar lateral nucleus [24] but not the motor cortex [25] provides input to this third component, it may be related functionally to quick responses, such as ocular reflexes involved in protection, rather than voluntary jaw and limb movements.
Our membrane lipid profile assay showed an overall increase in membrane unsaturated FA, which could be related functionally to an increasing expression/activity of these enzymes.
Fifteen CNV-loci were previously reported to be functionally related to or be associated with the investigated diseases (Table S2).
Using these criteria, we identified 21 CNA genes from A431 that are likely to be functionally related to damaging SNVs; the corresponding numbers for U251MG and U2OS were 46 and 51, respectively.
Interestingly, the development of mental state understanding is functionally related to executive functions, suggesting that the prefrontal cortex is implicated in self/other cognitive representations.
We found that AKH/AKHR signaling in the fat body, which is thought to be functionally related to glucagon/glucogon receptor signaling in the mammalian liver, positively regulates CRE-mediated transcription (Figure 5).
Recently, YaeT was suggested to be functionally related to SurA (Sklar et al., 2007).
Often, co-expressed genes within a cluster are expected to be functionally related to genes with a similar expression pattern.
