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This raises the possibility that heparanase may be regulating levels of SP1 within the nucleus.
Interestingly, synapsin genes and arc, among the main song-regulated genes identified so far, act at the pre-synaptic and post-synaptic levels, respectively, suggesting that song-regulated gene networks may largely exert actions at the level of synapses, where they could be regulating levels of experience-dependent plasticity.
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Thus, a key role of the promoter may be in regulating levels of gene expression.
Comparable to our previous observations [10], plasma levels of MCP-1 were significantly and approximately 30% reduced in p55−/−LDLR−/− mice, indicating that p55 TNFR signaling is important for regulating levels of MCP-1 in the circulation.
Both these proteins are important in regulating levels of serotonin in the brain and carry polymorphisms in their promoter regions that cause differential transcriptional activity and thus impact drug metabolism [22, 24 26].
Genes regulating levels of osmoprotectants are highly stress responsive and were among the first stress-inducible transcripts reported in the literature [ 28- 31].
Furthermore, similar findings for BCR-induced CD44 gene induction (Maltzman, J.S., J.A. Carman, and J.G. Monroe. 1996. Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes. Mol. Cell. Biol. In press) suggest that EGR1 may be an important signaling molecule for regulating levels of migration and adhesion molecules during humoral immune responses.
The observation that a Beclin 1 S90 phosphomimetic mutant can substitute for MK2/3 in MK2/3-deficient cells in regulating levels of autophagy is consistent with a model in which MK2/3 regulates autophagy through the phosphorylation of Beclin 1 S90.
Aromatase is therefore considered a crucial protein in regulating levels of male and female sex hormones in various tissues, including gonads, adipose tissue, placenta, and brain.
These in vivo and in vitro studies demonstrate that regulating levels of Vangl2 phosphorylation is a way to sense the Wnt5a morphogen gradient.
Studies describing the role of post - transcriptional mechanism in regulating levels of a number of miRNAs have been recently published [ 53, 76].
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