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Recent studies indicate that the sumoylation system can be regulated through multiple mechanisms, including the regulation of the expression of various components of the sumoylation pathway, and the modulation of the activity of SUMO enzymes.
These active kinases (about 12.3% of the kinome library tested) comprised a wide range of classes and functional groups, indicating that the cancer cell growth could be regulated through multiple genes and pathways.
The SUMOylation system can be regulated through multiple mechanisms, including the modulation of the expression of various components of the SUMOylation pathway, and the regulation of the activity of SUMO enzymes.
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Synthesis of MMPs is regulated through multiple MAPK families, suggesting that a blockade of MAPK might have structural benefit in arthritis [80], [81].
Glucose metabolism is regulated through multiple steps, including uptake, glycolysis and pyruvate decarboxylation.
During stress, the transcriptional activity of p53 is regulated through multiple posttranslational modifications.
Both ODC and AdoMetDC are regulated through multiple mechanisms, catalyze reactions in the earlier stages of polyamine biosynthesis, and their reaction products are committed to polyamine biosynthesis.
Transcript levels are regulated through multiple processes, including chromatin organization and modification, and effects of microRNAs and long non-coding RNAs.
The IL-12 production is regulated through multiple pathways that include: NF-κβ, p38 mitogen-activated protein (MAP) kinase, cyclic adenosine monophosphate (cyclic AMP -modulating molecules AMP -modulatinge (NO) [ 64].
The plethora of physiopathological events associated with brain ischemia are regulate through multiple signaling pathways leading to the activation of oxidative stress process, Ca2+ dyshomeostasis, mitochondrial dysfunction, proinflammatory mediators, excitotoxicity and/or programmed neuronal cell death.
Aromatase expression has been reported to be regulated through the alternative use of multiple exons 1 (exons 1a-1f and so on); however, the preferential usage of exons 1 in elderly breast tissue has never been systematically examined.
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