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These genes may be regulated through an antisense-mediated pathway.
As it has been shown that the expression of PCa-associated lncRNAs can be regulated by long terminal repeats (LTRs) [ 75], PCAT-114 might be regulated through an LTR in its 5′UTR (own unpublished observations).
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Furthermore, our results indicate the hepatocyte functionality appears to be regulated through a crosstalk between the Rho and Akt signaling.
The disparity between Slug protein and mRNA expression in gastric cancer vs. adjacent normal tissues suggests that Slug may be regulated through a post-transcriptional mechanism.
Our findings demonstrating that ADAMTS-12 could modulate JEG-3 cell-ECM adhesion in an RGD dependent manner suggested that ADAMTS-12-mediated cell invasion could also be regulated through a similar RGD/integrin-dependent mechanism.
Cell proliferation and many other cell processes can be regulated through a signaling pathway that involves an enzyme called PI3K.
For example, the stability of Jak2 seems to be regulated through a SOCS1-mediated proteasome pathway [ 48].
Translation efficiency of certain mRNAs can be regulated through a cytoplasmic polyadenylation process at the pre-initiation phase.
This unexpected result suggests that c-Myb protein levels may be regulated through a complex mechanism in MCF-7 cells.
Polyadenylation can be regulated through a short nucleotide sequence known as cytoplasmic polyadenylation element (CPE) located in their 3' UTR.
Maintenance of the stem cell character of pNBs is unlikely to be regulated through a competitive mechanism, since the pNB lineages contain only a single stem cell.
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