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Furthermore, our results indicate the hepatocyte functionality appears to be regulated through a crosstalk between the Rho and Akt signaling.
The disparity between Slug protein and mRNA expression in gastric cancer vs. adjacent normal tissues suggests that Slug may be regulated through a post-transcriptional mechanism.
Our findings demonstrating that ADAMTS-12 could modulate JEG-3 cell-ECM adhesion in an RGD dependent manner suggested that ADAMTS-12-mediated cell invasion could also be regulated through a similar RGD/integrin-dependent mechanism.
For example, the stability of Jak2 seems to be regulated through a SOCS1-mediated proteasome pathway [ 48].
Translation efficiency of certain mRNAs can be regulated through a cytoplasmic polyadenylation process at the pre-initiation phase.
Cell proliferation and many other cell processes can be regulated through a signaling pathway that involves an enzyme called PI3K.
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These genes may be regulated through an antisense-mediated pathway.
As it has been shown that the expression of PCa-associated lncRNAs can be regulated by long terminal repeats (LTRs) [ 75], PCAT-114 might be regulated through an LTR in its 5′UTR (own unpublished observations).
Notably, biological network analysis shows that several of the genes modulated by the intestinal microbiota are regulated through a general xenobiotic regulator, the nuclear receptor CAR (Figure 2).
The expression of B. pseudomallei katG and ahpC is regulated through a global H2O2 sensor and the OxyR transcriptional regulator [ 21– 23].
We suggest that Lid2 enzymatic activity in euchromatin is regulated through a dynamic interplay with other histone-modification enzymes.
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