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Chromatin conformation is thought to be regulated not only by histone modifications, but also by DNA methylation.
These Nodal target genes are therefore likely to be regulated not only by Nodal signaling but additional factors.
ABCB1 expression has been shown to be regulated not only by histone acetylation, but also by DNA methylation.
IP-10 expression within inflamed joints appears to be regulated not only by inflammatory cytokines but also by the physical interaction of activated leukocytes with FLSs.
Thus gene expression can be regulated not only by modulating transcriptional parameters but also by using post-transcriptional parameters like using optimal codons or by including 5′ and 3′ leader sequences.
In cell death-related processes, the Bim pathway seems to be regulated not only by the transcriptional activation of Bim[ 46] but also by other mechanisms, such as phosphorylation or proteasomal degradation of Bim protein [ 47] and binding to anti-apoptotic molecules, including Bcl-2 and Bcl-XL [ 48].
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Consistent with the known biology of melanocyte cell regulation (Yamaguchi and Hearing 2009), our data suggest that skin color is regulated not only in the pigment layer of the epidermis, but also from within the dermal layer of skin.
Tiller bud outgrowth is regulated not only by endogenous factors, but also by environmental signals (Xing and Zhang 2010).
SREBP1c processing is regulated not only by nutrient status but also by hormonal signaling during feeding and fasting (Horton et al., 1998; Li et al., 2010).
Expression of Hox genes is regulated not only at the transcriptional but also at the post-transcriptional level.
The inhibitory function of p27Kip1 is regulated not only through synthesis and degradation, but also by sub-cellular localization.
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