Sentence examples for be regulated largely by from inspiring English sources

In contrast, Nox4 does not have a requirement for additional regulatory subunits, has constitutive low-level activity, and seems to be regulated largely by changes in abundance [52 55].

Previous studies on the control of gene expression in vector-derived L3 versus 24 hour p.i. L3 highlighted a number of mRNAs which appeared to be regulated largely by the temperature shift associated with infection [ 62].

Thus, the variation in leaf photosynthesis among species was regulated largely by changes in LMA, rather than the concent of nitrogen in leaf tissue.

The results presented here provide the first evidence of large scale regulation of c-Myb activity and specificity in cells that are in different growth phases, suggesting that c-Myb is regulated largely by protein-protein interactions that help guide it to different target genes in different types of cells.

Although no genes encoding NF-κB family proteins are direct children of IL6, we have previously suggested that the NF-κB family do not appear in gene networks [ 17], since the activity of this family are regulated largely by post-transcriptional mechanisms.

Although VEGF expression is regulated largely by hypoxia and mainly involved with CNV in neovascular AMD, VEGF/PEDF ratio favoring angiogenesis may promote drusen accumulation and trigger progression towards CNV in smoker patients with dry AMD (Pons and Marin-Castano, 2011).

It is well known that p21 expression is regulated largely at the transcriptional level by a p53-dependent mechanism at the transcriptional level [ 46], which suggests that Oct-4 may regulate p21 expression through the p53 tumour suppressor gene.

Because MOMP effectively represents a point-of-no-return, it is highly regulated, largely by members of the BCL-2 protein family.

This type of result has been discussed as an example for the theory of developmental systems drift, which proposes that conserved developmental and morphological structures can be regulated by largely diverse regulatory mechanisms [ 51].

These are not things that China (or Russia, which also plans to build a fair few plants) has yet shown it can provide.In any country independent regulation is harder when the industry being regulated exists largely by government fiat.

However, the signaling mechanisms by which Caskin proteins are regulated are largely unknown.