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Finally, the model shows how the whole system might be regulated in development and dysregulated in cancer.
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In this review, we explore recent advances in the current understanding of how TET expression and function are regulated in development and cancer.
Understanding how this pathway is regulated in development remains a major challenge.
Current research into epigenetic mechanisms aims at an understanding how the genome is regulated in development and disease.
ChIP is now a standard assay used to identify and study protein-DNA interactions, with its use greatly enhancing our understanding of how the genome is regulated in development and disease, and how it has evolved over time.
While Lim domain proteins are known to be regulated in embryonic development and in cancer it is postulated that Ablim3 functions as linkage between the actin cytoskeleton and signaling pathways [191].
We hypothesized that they are caused by uncontrolled, excessive myelin membrane growth, a process, which is regulated in normal development by neuregulin-1/ErbB2, PI3 Kinase signalling and ERK/MAPK signalling.
To determine if any of these core cell cycle genes were regulated in fruit development, we identified apple homologues and examined their expression.
How the sequential specification of neurons and progressive loss of potency associated with aging neural progenitors are regulated in vertebrate brain development is poorly understood.
However, little is known about how Mef2 activity is regulated in vivo during development.
Foxa genes are regulated in early mouse embryo development [66] and are responsible, at least in part, for metabolic regulation.
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