Initiation of autophagy is regulated either through the PI3K/Akt/mTOR pathway [ 7] or through the LKB1/AMPK/mTOR pathway [ 8, 9].
HSC self-renewal and differentiation are regulated either through contact-dependent signals, such as VCAM-1 [136], or via soluble factors such as SCF [137].
The NAD-dependent protein deacetylase SIRT1 has a wide range of different targets, which may be regulated either directly through deacetylation and thus potentially altering their activity or localization or indirectly by deacetylation of histones, which in turn alters their transcription rate and availability.
Thus, a potentiating effect of the COOH-STIM2 antibody indicates that the strength of the STIM2-Orai interaction might be regulated, either positively or negatively, through a site that is affected by the antibody, indirectly confirming the central role of STIM2 during Tin generation.
In mammalian cells, autophagy initiation is regulated either by growth factors through the PI3K (phosphoinositide 3-kinase)/Akt/mTOR (mammalian target of rapamycin) pathway [ 7] or by nutrients through the LKB1/AMPK (AMP-activated protein kinase)/mTOR pathway [ 8, 9].
The function of proteases is regulated either by controlling the spatial and temporal activity or through their ability to discriminate among potential substrates, of which the last is probably the most important mechanism.
"In District of Columbia v. Heller, you wrote that 'unless guns were regulated either at the time the Constitution was written or traditionally throughout history, they cannot be regulated now.'".
Moreover, the swelling property of the hydrogel can be regulated through the content of MWCNT-PAA.
These three municipal laws will be regulated through the towns' building departments.
Roberts called for unions to be regulated through competition law and the Australian Competition and Consumer Commission.
