With default settings of a minimum of 3 probes matching to a de novo annotated transcript, 6,533 transcripts were found to be significantly regulated, corresponding to 2,626 genes.
Other adipokines visfatin and apelin are also regulated corresponding to n-3 PUFA treatment without alteration in circulating levels, suggesting that both of them are incompetent to mediate systemic influence [ 101].
Our goal was to determine if the genes within the network could be regulated by treatments corresponding to receptors within this gene network.
Column 6 of Table 3 shows that a large number of genes in individual modules are already reported to be regulated by the corresponding transcription factor.
Overall, at least 50% of the supported target genes tested in this study appeared to be regulated by their corresponding microRNA either directly or indirectly which is significantly better than the result of ordinary bioinformatic prediction with only 10% of correctly predicted target genes.
Therefore, most of the genes with the identical signature could be regulated by the corresponding miRNA.
In total, 124 probes corresponding to 117 genes were found to be regulated, with 27 genes downregulated and 90 (97 probes) upregulated.
Even if the expression profiles of not all the genes in the same operon are well correlated with the expression of a certain regulator gene, we assume that all the genes in the same operon will be regulated by the regulator provided that the corresponding binding sites are found in the upstream regulatory regions of the operon.
On the one hand, this suggests that more cis elements in aUTRs can be regulated by APA for the corresponding genes; on the other hand, longer aUTRs may allow more effective regulation of proximal poly(A) sites with less interference from distal poly(A) sites.
Departing from the dynamic error between the desired and the current substrate concentration trajectories a control law is designed and the plant is regulated to the corresponding set point of the COD concentration.
