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The phosphorylation of the NCC/NKCC ion transporters by WNK kinases appears to be regulated by two complementary systems: the regulation of total WNK protein levels by CUL3-KLHL3, and the level of WNK activation by phosphorylation.
In most cases, one miRNA can target many different mRNA genes; In contrast, one mRNA can also be regulated by two or more miRNAs.
MLCP has been reported to be regulated by two mechanisms: (i) RhoA activates Rho kinase (ROK) [23] which inhibits MLCP by phosphorylating [Thr855]MYPT, the regulatory subunit of MLCP [24-26] [24-26]
In rhesus macaques, luteinizing hormone (LH) secretion appears to be regulated by two distinct gonadotropin-releasing hormone (GnRH) neuronal populations, which can be distinguished by their unique anatomical locations and because they express different molecular forms of GnRH (GnRH-I and GnRH-II).
We speculate that this process may be regulated by two pathways.
Thus, RIG-I is likely to be regulated by two different modes of modifications.
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A Rho GTPase switch can be regulated by three classes of regulators: GE Fs GAPs, and GDIs.
Moreover, it was described that EZH2 can be regulated by miR-26 [24] and miR-214 [25].
SIRT1 were observed to be regulated by miR-9 in stem cells [28].
The canonical pathways predicted to be regulated by miR-486 are phenylalanine and cyanoamino acid metabolism, insulin receptor signaling, antigen presentation, and pentose phosphate pathways.
From the analysis, we found that LPS/IL-1 and toll-like receptor signaling are among the top five canonical pathways predicted to be regulated by miR-146a.
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CEO of Professional Science Editing for Scientists @ prosciediting.com