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More than 50 genes have been shown to be regulated by this mechanism, among these the cell cycle regulators p21, p27, c- fos and c- myc.
Diverse biological processes such as gene regulation, DNA repair, and chromosome condensation seem to be regulated by this code.
This indicates that a substantial part of the 25(OH D-associated genes may directly be regulated by this secOH D-associatedplies indirect 25(OH)D-mediated regenesion of the remayning 27 genes or the presence of regulatory elements in regions that were not includirectlyhe analysis (e.g., within exons or introns, the 5′ or 3′ UTR).
Based on miRNA-gene regulations, given one miRNA, a module will be regarded to be regulated by this miRNA if its target genes are significantly enriched in this module, where the enrichment analysis was conducted with Fisher exact test with P-value cutoff of 0.01.
The positive association between MMPs and TIMPs suggests that in healthy individuals, enzyme activity may be regulated by this interaction.
On the other hand, HIF-1 DNA binding activity was increased as well as the expression of several genes known to be regulated by this factor.
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Several genes are involved in carcinogenesis, and many of them are related to the proper functioning of TP53, either by regulating or being regulated by this gene.
Processes like photosynthesis, fragrance emission and time of bloom are regulated by this timekeeping mechanism.
It is thought that the Ach is broken down immediately by AChE and enterokinesis is regulated by this reaction.
As cyclins are typically regulated by controlling their abundance within the cell, a study was undertaken to determine whether cyclin C was regulated by this mechanism.
Eph/ephrin signaling has been implicated in notochord morphogenesis in zebrafish [12], [13], though it is unknown which step of notochord development is regulated by this signaling.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com