In addition to transcriptional regulation, Ezh2 transcript is known to be regulated by several micro-RNAs.
The expression of one gene can be regulated by several miRNAs, presupposing multiple methods of gene regulation that include dependence on the expression of intronic miRNAs.
MEF2 activity can be regulated by several mechanisms, including phosphorylation by p38 MAP kinase, a calcineurin-regulated acetylation/sumoylation switch, and an indirect mechanism involving phosphorylation-regulated recruitment of class II histone deacetylases (Berdeaux et al., 2007; Han et al., 1997; Shalizi et al., 2006; Zhang et al., 2002).
Data regarding the regulation of sEpoR is limited, although membrane bound EpoR is known to be regulated by several cytokines such as TNF-α, IL-1β, and IL-6 [55], [55].
It is important to note that other splicing events may not behave in a similar manner to these specific splicing targets, since they might contain different cis-elements and be regulated by several different splicing factors simultaneously.
Even the same mRNA sequence can be regulated by several micro-RNAs bound up to it [5].
However, the processes of translocation of TiO2 NPs into the brain would be regulated by several parameters, such as administration routes, size, and surface modification.
Microglial activation, which plays a central role in neuroinflammation may be regulated by several intercellular interactions involving cell-surface molecules and soluble mediators, such as cytokines, reactive oxygen species (ROS), and neurotransmitters [22].
AQPs are reported to be regulated by several stresses, particularly drought, and shoots transpiration (Martre et al. [2001], [2002]; Clarkson et al. [2000]; Martínez-Ballesta et al. [2003]; Shimizu et al. [2005]; Sakurai-Ishikawa et al. [2011]; Laur and Hacke [2013]; Chaumont and Tyerman [2014]) often without any change in root anatomy or morphology.
SP1 has been reported to be regulated by several post-translational modifications, including phosphorylation, acetylation, ubiquitination and sumoylation [36].
This is supported by recent findings that expression of beta carbonic anhydrases may be regulated by several factors including CO2 and light [39].
