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DNA binding may be regulated by sequences bordering the Ets; for instance, ETS1 DNA binding is inhibited by two helices flanking each side of the Ets.
TNIP1 encodes the tumour necrosis factor alpha inducing protein 3 (TNFAinteractingcting protein, which inhibits NF-kB activation by tumour necrosis factor (10), and could conceivably be regulated by sequences within the region of association with CD.
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IFNβ RNA is regulated by sequences in the 3' UTR that mediate rapid turnover of the RNA [51].
Nucleo-cytoplasmic trafficking of NFAT5 is regulated by sequences located within its amino-terminal region, preceding the Rel-like DNA-binding domain.
The findings here suggest that Ape1 ssAP and dsAP endonuclease activities are regulated by sequence context and the relative concentrations of certain chemical elements in vivo, and that Ape1 incision activity occurs on complex replication, recombination, and/or transcription DNA intermediates.
Viral RNA translation and replication are regulated by sequence and structural elements in the 5' and 3' untranslated regions (UTR) and by host cell and/or viral proteins that bind them.
In addition, transcription initiation is regulated by sequence-specific transcriptional activators and repressors.
Eight genes out of the 12 selected genes had promoter elements identified by the primer extension assays to match those identified by the computational predictions, and six of these eight genes were found to be regulated by promoter sequences highly similar to other bacterial RpoN promoter elements (Table 3).
These isoforms might be regulated by different regulatory sequences, but the same sequences might influence more isoforms based on their position (OTTHUMG00000036946 in the VEGA database).
This phenomenon was originally noticed through the elucidation of individual cases where host genes were found to be regulated by TE-derived sequences [ 8, 9].
BLASTing the 15-bp PORE sequence revealed a large cohort of genes potentially regulated by such a mechanism (although osteopontin, the one target gene previously known to be regulated by a PORE sequence, was not identified in this analysis).
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