However, the DXS protein level was only 1.5-fold higher, leading to the assumption that the level might be regulated by post-transcriptional events.
The activity of DGAT1 was proposed to be regulated by post-translational modification (Yu et al. 2002) and PKA might be the upstream regulator (Haagsman et al. 1981 , 1982 Rodriguez et al. 1992).
Nuclear import of Trx is also suggested to be regulated by post-translation modification of Trx on cysteine 69 [60].
However, since PTP activity could be regulated by post-translational modifications that are not present in protein expressed in bacteria, results depend on the expression system used [23].
The transcriptome and the proteome diversity have been shown to be regulated by post-transcriptional RNA processing mechanisms; the best studied being alternative splicing [6].
However, the nucleosome is in a dynamic state that can be regulated by post-translational modifications and/or remodeling, which is important for a number of cellular events ranging from gene transcriptions [56], [57] to DNA break repairs [58].
Given that the activity of Dishevelled and Vangl can be regulated by post-translational modifications [37], the fact that their expression was not modified is not in itself a proof of them not being involved in Wnt4 signaling.
Furthermore BAMBI mRNA levels in endothelial cells appear to be regulated by post-transcriptional mechanisms depending on de novo protein synthesis, as cycloheximide markedly increased mRNA levels for BAMBI in both mGECs and HUVECs (Figure 6B).
This suggests that AADs may not work constitutively, but may be regulated by post-translational modifications.
The association with these factors can also be regulated by post-translational modification of PCNA [12].
SETD6 is ubiquitinated within the SBD at lysine 441, suggesting that substrate specificity could be regulated by post-translational modifications.
