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The activity of PKM2 can be regulated by numerous allosteric effectors and posttranslational modifications (PTMs) that could change its conformation.
Transcriptional activation of the Ccnd1 and Jun genes cannot be taken to be absolutely specific for the Wnt/β-catenin pathway, since both of these genes can be regulated by numerous other factors.
Promoter activity may also be regulated by numerous modifications of the histones associated with the promoter.
VEGF expression is known to be regulated by numerous cytokines and growth factors (Akagi et al, 1998).
Autophagy and apoptosis have been shown to be regulated by numerous aspects of glucose metabolism and can also be activated by mitochondrial dysfunction and oxidative stress [ 37].
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Vascular endothelial growth factor (VEGF), perhaps the most critical regulator of angiogenesis in both tumours and normal tissue, is regulated by numerous factors, most notably tissue oxygen level (Shweiki et al, 1992).
In most tissues, Cox-2 requires activation by inflammatory or other stimuli and is regulated by numerous 5′ transcription factors in addition to post-transcriptional regulation through elements at the 3′ untranslated region of the gene [ 3].
Marriage is regulated by numerous incest taboos.
Charitable activities are regulated by numerous bodies, from HMRC to the Fundraising Standards Board, but it was the Charity Commission's change programme, back by millions in additional government funding, which dominated the debate.
Patterns of gene expression in multicellular eukaryotes are regulated by numerous extremely sophisticated mechanisms.
The bioactivity of these growth factors is regulated by numerous mediators.
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