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Thus, progression of the cell cycle can be regulated by modulating the quantities of cell-cycle regulators through ubiquitination by the SCF complex [ 1].
Microtubule-dependent intracellular trafficking may therefore be regulated by modulating the activity of HDAC6.
Transcription factor activity can be regulated by modulating subcellular localization, which is often achieved through post-translational modification including phosphorylation and dephosphorylation.
The pattern of signal transduction between different parts of the network, therefore, may be regulated by modulating the expression levels of central proteins, thereby fine-tuning network behavior according to the conditions at hand.
In addition, it would be worth investigating how the CAF-1 molecular pathway can be regulated, by modulating the expression of its subunits and their interactions with the other histone chaperones and ATP-dependent chromatin remodelers.
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Besides, the active/reactive power to the grid is regulated by modulating the inverter.
SRF driven transcription of specific gene promoters can be regulated by different mechanisms, including modulating the level of SRF expression, SRF phosphorylation, nature and number of CArG boxes in the target gene, RhoA-mediated alterations in the cytoskeleton and association of SRF with different context or cell-specific co-factors.
FLNs appear to be regulated by the thioredoxin system that modulates enzyme activities in response to illumination, which for FLNs, requires a specific thioredoxin, TRX-z [ 15]. trx-z null plants are viable and develop morphologically normal leaves abeit without chlorophyll when supplied with sucrose [ 15].
Several lncRNAs have been shown to be regulated by p53 or to modulate apoptosis in response to DNA damage, for example, Pint and Panda have anti-apoptotic activity, whereas INXS, MEG3, lincRNA-p21 and Gas5 all have pro-apoptotic activity.
These results were extended to spinally projecting neurones within this nucleus, whose firing was regulated by NO modulating the GABAergic tone (Li et al., 2002, 2003).
In sorghum, SbCN8 and SbCN12 are potential sources of florigen because expression of both genes is regulated by photoperiod, modulated by Ma1 alleles, and induction of expression occurs coincident with floral initiation [ 1].
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