These researchers insightfully argued that "the in vivo proteolytic activity and the in vivo substrate specificity of the proteasome may be regulated by modification of its subunit composition during fly development" (Haass and Kloetzel, 1989).
Carrot growth and development may be regulated by modification of the genes involved in gibberellin biosynthesis, catabolism, and perception.
This process is regulated by modifications in chromatin remodelling, mainly H3K4me3 in HLA-B, and β2m, as well as H3K9me3 in TPN gene, respectively.
Since the identification of a cyclin partner would allow us to assess whether Lsk1p activity was regulated by modifications in cyclin stability and/or localization we decided to determine whether such a physiologically relevant cyclin sub-unit existed in S. pombe.
It is likely that the functional role of unstable proteins is regulated by their continual synthesis and degradation, while longer-lived proteins are regulated by modifications such as phosphorylation and acetylation.
In the case of TDG, which binds AP-sites very rigidly, dissociation is regulated by modification of a C-terminal lysine residue with small ubiquitin-like modifiers (SUMOs).
Human cells have processes such as DNA methylation, histone modifications, and ncRNA that can be regulated by epigenetic modifications [ 74].
Furthermore, TE activity can mediate genomic rearrangements, which may be regulated by epigenetic modifications such as DNA methylation and histone modification [ 79].
We investigated whether the post-expansion redifferentiation and cartilage tissue formation capacity of adult human nasal chondrocytes can be regulated by controlled modifications of scaffold composition and architecture.
Recently, we characterized a major histone methyltransferase (HMTase) gene SET DOMAIN GENE 724 (SDG724), which is required for Histone H3 lysine 36 (H3K36) methylation, promotes rice heading, indicating that rice flowering could also be regulated by chromatin modifications (Sun et al., 2012).
For instance, CAND1 binding to cullin proteins may be regulated by posttranslational modifications in either of the proteins or by other interacting proteins.
