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These researchers insightfully argued that "the in vivo proteolytic activity and the in vivo substrate specificity of the proteasome may be regulated by modification of its subunit composition during fly development" (Haass and Kloetzel, 1989).
Carrot growth and development may be regulated by modification of the genes involved in gibberellin biosynthesis, catabolism, and perception.
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In the case of TDG, which binds AP-sites very rigidly, dissociation is regulated by modification of a C-terminal lysine residue with small ubiquitin-like modifiers (SUMOs).
This process is regulated by modifications in chromatin remodelling, mainly H3K4me3 in HLA-B, and β2m, as well as H3K9me3 in TPN gene, respectively.
Since the identification of a cyclin partner would allow us to assess whether Lsk1p activity was regulated by modifications in cyclin stability and/or localization we decided to determine whether such a physiologically relevant cyclin sub-unit existed in S. pombe.
It is likely that the functional role of unstable proteins is regulated by their continual synthesis and degradation, while longer-lived proteins are regulated by modifications such as phosphorylation and acetylation.
Several studies have indicated that the mechanism of the allelic-specific expression could be regulated by epigenetic modification, including DNA methylation and various histone modifications [ 52, 53].
First, expression of pro-metastatic Ezrin can be regulated by epigenetic modification, thus representing a model for assessing the relationship between epigenetic modification and metastasis.
Other gene (especially CDKN2A) may be regulated by epigenetic modification.
Importantly, BAG3 function and levels can also be regulated by posttranslational modification.
This control is thought to be regulated by posttranslational modification (PTMs) of histones occupying key lytic and latent viral promoters (Fig. 2).
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