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In these cell lines, miR-328 may not be the major regulator of CD44 since CD44 can also be regulated by many other miRNAs.
Given the involvement of p21 in multiple cellular processes ranging from differentiation to cell cycle regulation and cell death, one would expect it to be regulated by many factors and therefore it is unlikely that TBX2 would repress p21 in all cellular contexts.
They can be regulated by many different mechanisms [1], [5] [7].
The result showed that each miRNA could regulate many target genes, from several to hundreds, and some development-associated genes could be regulated by many miRNAs (Table S7).
As an miRNA-targeted gene, VEGF might be regulated by many miRNAs, according to the number of binding sites in its 3'-UTR.
Since a single gene can be regulated by many miRs, we obtained a list of 10 miRs in Targetscan 5.1 (http://www.targetscan.org) that putatively target HB-EGF and found that only miR-212 showed a significant difference between SCC1 and 1Cc8 (Figure 4B).
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According to our analysis, homeobox proteins are involved in the regulation of or are regulated by many protein families such as GPCRs, ion channels, tyrosine phosphatases, nuclear hormone receptors, and protein kinases.
Interestingly these genes were regulated by many of the same regulators that control expression of virulence factors for the plant host but in opposite directions [ 97].
Recruitment, proliferation, and differentiation of MSCs into mature osteoblasts are regulated by many factors including cytokines, systemic hormones, growth factors, and other regulators [ 14].
Human brown adipocytes are regulated by many intrinsic factors, including glucocorticoids and bile acids.
Differentiation of mesenchymal stem cells (MSCs) into anterior cruciate ligament (ACL) cells is regulated by many factors.
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