Sentence examples for be regulated by direct from inspiring English sources

Therefore, taken together, these results suggest that BHMT activity can potentially be regulated by direct redox-regulation of critical cysteine residues via Nox4-generated H2O2.

In addition, (AnxA2 2- p11 2 association to the plasma membrane seems to be regulated by direct binding of the heterotetramer to phosphatidylinositol (4,5) bisphosphate [34], [35] and p11 itself seems to play a role in the trafficking of some ion channels and receptors — reviewed in [8].

For example, Tiam1 is known to be regulated by direct binding to activated Ras [ 54].

Alternatively, the amount and thus activity of Cas9 can be regulated by direct delivery of recombinant Cas9 protein (Kim et al. 2014b; Ramakrishna et al. 2014).

Therefore, dysregulated genes at 16 h would reflect the direct consequence of decreased Baf250a protein, whereas those after 16 h may be regulated by direct transcriptional targets of Baf250a.

Recent advancements have shown that small-molecule compounds can induce pluripotency, indicating that cell fate can be regulated by direct manipulation of intrinsic cell signaling pathways, thereby innovating our current understanding of reprogramming.

Thus it will be important to determine the fraction of co-regulated genes whose expression is regulated by direct binding of NR3C1 versus other indirect mechanisms of regulation.

Free, R. B. et al. D1 and D2 dopamine receptor expression is regulated by direct interaction with the chaperone protein calnexin.

Temmei, Y. et al. Water channel activities of Mimosa pudica plasma membrane intrinsic proteins are regulated by direct interaction and phosphorylation.

Ubp3 is targeted to stress-responsive genes by Hog1, and its activity is regulated by direct phosphorylation by Hog1.

CREB activity is regulated by direct phosphorylation at Ser mediated by the kinases MSK1/2 [ 18] and via interactions with co-activators called CRTCs [ 19].