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These data are consistent with the idea that cleavage in vivo could be regulated by alternative RNA structures.
At post-transcriptional level, most JAZ genes can be regulated by alternative splicing.
Therefore, highly repressive MREs may not necessarily be regulated by alternative splicing.
However, it was reported that p21 activation inhibits p-CDK1 and results in G2/M arrest, suggesting that p-CDK1 may be regulated by alternative pathway mechanisms and different cancer types may be regulated by different pathways.
As the p53 p21 axis is important in the regulation of CaP radiosensitivity, the deficiency of p53 in PC-3 cells suggests that p21 may be regulated by alternative mechanisms in this cell line.
Human studies show that SULT1A1 can be regulated by alternative promoter usage [ 32], SNPs in the coding or promoter region [ 26, 27], CNVs [ 28], or variants in the 3′UTR of the gene [ 13].
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Alternative splicings often occur in a spatiotemporal manner, and some are regulated by alternative splicing regulators.
Epstein, J. A. et al. Two independent and interactive DNA-binding subdomains of the Pax-6 paired domain are regulated by alternative splicing.
Interestingly, some of these mutants indicate that the formation of primary-, seminal-, crown- and lateral roots is regulated by alternative root-type-specific pathways.
Previous research focusing on gliomas that Califano conducted in collaboration with Antonio Iavarone and Anna Lasorella, for example, showed that the mesenchymal and proneural cell states are regulated by alternative tumor homeostasis mechanisms.
Here, we report that PTPRQ can be expressed as a cytosolic or a receptor-like protein and that the form, subcellular localization, and cell types in which it is expressed are regulated by alternative promoter use and by alternative splicing.
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