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It is well known that miRNAs act within a complex network of regulation, and it is formally possible that Nestin may be regulated by additional miRNAs.
Considering that only two time points were tested, the researchers suspect that refractive eye development may be regulated by additional genes and pathways, which could be identified with additional experiments.
Furthermore, it is important to note that IRES dependent translation may also be regulated by additional factors that are not present in K cells.
Given these findings, we were wondering whether HCN channels may be regulated by additional, not yet specified proteins, and in particular by protein kinases.
PAS domain proteins can also be regulated by additional redox-active compounds, including Heme, the Heme breakdown product CO gas, as well as NO gas.
Two (beta-actin 1 and cyclin E) of the three control genes showed significant Spt5 occupancy (Fig. 5C and Table 1), whose expression was largely unaltered in 24 hpf fogsk8 embryos, suggesting that these transcripts might be regulated by additional elongation factors.
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It remains unclear whether MreB's curvature preference is regulated by additional factors, and which specific features of MreB promote specific features of rod shape growth.
While this may be because the mediator complex is already saturated with myc-Cdk8, it might also suggest that association of Cdk8 with the complex is regulated by additional signalling pathways and that the level of cyclin C is not rate limiting.
Indeed, blood pressure is regulated by additional mechanisms like vasoconstriction.
However, VEGF is also expressed in a considerable number of HER2-negative tumors, suggesting that its expression is regulated by additional processes in breast cancer.
If the enzyme is regulated by additional factors, more parameters are added (e.g. Ki for affinity to an inhibitor; Ka for an activator).
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