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The duration and magnitude of MAPK activation may be regulated at many locations along the signaling pathway, but a major point occurs at the MAPK level [79].
TTP activity can be regulated at many levels: gene expression; mRNA stability; nucleocytoplasmic shuttling; phosphorylation; protein binding; and others.
OxPhos is a complex process, and its efficiency may be regulated at many different levels.
It is clear that this huge assembly of proteins must be regulated at many levels and is not dependent on DNA sequence.
Alternatively, binding of transcriptional activators to a priori methylated DNA episomes has been shown in replicating cells to lead to demethylation of those sequences., Since mRNA abundance can be regulated at many levels, further experiments will be needed to determine whether such mechanisms account for the changes observed in our rats.
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Although much emphasis was placed on changes in transcriptional regulation, gene expression is regulated at many levels.
The activity of the inhibitory Smad, Smad7, is regulated at many levels, suggesting that they serve as key regulators for fine-tuning the responses to TGF- β signalling.
The chapter defines that signaling pathways are regulated at many different levels, i.e. extracellularly, in the cytoplasm and in the nucleus.
The immune system is regulated at many levels by microRNA action, including differentiation and proliferation of myeloid lineages, and cellular responses to proinflammatory stimuli [18].
The fine-tuning of insulin synthesis, storage and secretion is regulated at many levels of gene expression, ranging from transcription, mRNA stability to translation and folding [8].
Here, the ΔMosec22 mutant hardly produced conidia or appressoria at the tips of the hyphae, all suggesting that conidiogenesis and appressorium formation are regulated at many levels and proteins including those functioning in membrane trafficking.
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