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MMPs are known to be regulated at different levels; this study indicates that, in endothelial cells, the stimulation of MMPs can also occur at the level of secretion, a mechanism that provides a rapid mobilization of these crucial enzymes in the early phases of angiogenesis.
It is reasonable to suggest that SOX2 expression may be regulated at different levels; at the DNA, mRNA and protein and that it may be important to assess for its expression at all three levels.
These results suggested that the genetic mechanisms underlying body growth and development are complicated, and the genes contributing to the body plan are in various networks and they might be regulated at different developmental stages, a fact known to biologists.
Other QPX peptidases for which expression was shown to be regulated at different temperatures were subtilases.
It is clear that HIF3α can be regulated at different levels.
Data from this study support the hypothesis that miR-140 expression could be regulated at different levels under normal and OA conditions.
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Down-regulation was dominant at most time points and distinct sets of genes were regulated at different stages.
"From a policy perspective, it's a really tricky issue, given that energy and water are regulated at different scales and in different ways," said John Rogers, a senior energy analyst with the Union of Concerned Scientists.
The spatial organization and dynamics of nucleolar proteins and RNA is regulated at different structural levels, which finally determine nucleolar architecture.
Thus, ICK/KRP degradation is regulated at different levels during pollen development (Figure 5).
The binding capacity of tau to microtubules is regulated at different levels.
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