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Interestingly, HIV-1 Gag assembly appears to be regulated at an early step of nuclear export of singly spliced and unspliced mRNAs [23], [24].
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There is also the possibility several indirectly regulated proteins may be regulated at a tertiary level involving secondary regulators that control expression of additional tertiary transcription factors that subsequently affect cyst development (Fig. 4).
For example, mRNA levels in Drosophila [68] were found to be regulated at a post-transcriptional level without evident transcriptional regulation; however, simultaneous inhibition of both Erk and p38 kinase pathways decreased the levels of cytokine gene transcription (IL-6 and TNF-α) [69].
The data show that planktonic bacteria seem to be regulated at a landscape scale controlled by land use, whereas biofilm bacteria are regulated at a biofilm matrix scale controlled by autochthonous production.
Even if the protein is reduced in the Western Blot, this reduction may not be regulated at a transcriptional level, it may happen at a post-translation level.
We then investigated the question of whether or not Wnt signaling-induced PLD expression might be regulated at a transcriptional level.
Shen and colleagues [54] however have shown that exercise-induced regulation ERK occurs in a delay dependent manner, and it is possible in our experiments ERK may be regulated at a time point other than that we investigated.
Gene expression in mammalian cells can be regulated at a single or multiple levels involving chromatin structure, transcription, post-transcription and translation leading to different genes being expressed at widely varying levels in a cell type-specific manner or in the same cell.
Therefore the induction of 20-HETE must be regulated at a step proximal to CYP4A expression and is likely due to increases in substrate delivery by increased generation of AA via cPLA2 activity or at the re-acylation of AA into membrane phospholipids as previously described [44].
Gene expression can also be regulated at a later, post-transcriptional stage [ 52, 53].
At least six of the proteins found in the proteomics assay seem to be regulated at a post-transcriptional level.
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