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These cells are thought to be refractory to classical chemotherapy and responsible for metastasis and relapse.
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In most countries, anti-TNF-α therapy is reserved for patients who are refractory to classical DMARD therapy.
Mediator is representative of a large number of macromolecular complexes that are refractory to classical high-resolution structural approaches, due to low native abundance and to conformational and compositional heterogeneity.
Chronic vulvovaginal pruritus can be refractory to standard treatment.
Thus, EWSR1 aggregates appeared to be refractory to Hsp104A503S.
Some of these reactions may be refractory to conventional therapy.
But they also noted that hypnotherapy helped "even those whose conditions were refractory to other forms of therapy".
She was refractory to any treatment proposed.
All patients were refractory to anti-TNFα treatments.
The cyanosis was refractory to oxygen (FiO2 = 1).
Nine patients were refractory to the pharmacological treatments.
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