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As PBMCs may be reflective of systemic changes in the body (Rudkowska et al., 2011), we wanted to determine if diabetes could affect renal mitochondria.
Case reports have indicated that gingival hemorrhaging can be reflective of systemic microvascular pathology for scurvy (6), hemorrhagic fever (7), leukemia (8), vitamin K deficiency (9), and von Willebrand disease (10).
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Based on our new GCMS method, drug quality parameters like bioavailability and bioequivalence could be estimated accurately based on pharmacokinetic measures such as AUC and Cmax that are reflective of systemic exposure.
These epidemiological findings support the hypothesis that retinopathies are reflective of systemic microvascular injury.
As early as 1988, such findings have led to the hypothesis that retinal microvascular changes are reflective of systemic microvascular injury present in tissues ranging from the kidney to the heart (2).
As pulmonary selective vasodilators have been reported to worsen left-sided heart filling pressures and induce pulmonary edema in patients with PH due to HFpEF, the significant increase in flow without an increase in PAWP might be reflective of the systemic effects of riociguat.
An increase in serum globulin levels may be reflective of a mild systemic immune response [ 63].
The hyperoxia could be reflective of the physiological interventions following major systemic trauma.
Our findings indicate that it is important to interpret pharmacokinetics information in a pharmacokinetics/pharmacodynamics context as similar systemic drug exposure in adults and children may not be reflective of the corresponding target occupancy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com