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Grain size estimates could be refined using information from analogue sub-Plinian eruptions at other volcanoes.
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To obtain more information about the material structure, the diffractograms were refined using the Pawley method [33] carried out with Fityk 0.98 software, as reported by Wojdyr [34].
Specific regression models were refined using a statistical selection procedure: successive variable elimination based on Akaike's Information Criterion.
The model building was performed in Coot34, and the structures were refined using phenix.refine.refine
Hydrogen atoms were refined using the riding model.
The native structure was refined using PHENIX.
The three binary complexes were refined using phenix.refine (Afonine et al., 2012).
Each timeline was then refined using information gained from the document review and interviews.
Our method finds a set of alternatives that are consistent with the dynamic data available and that can be further refined using additional information and expert knowledge on the system.
The results shown are already refined using zone information and instruction duration test.
Parameters were subsequently refined using biological information, if any existed, from the primary literature.
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