In the second step, the clusters are refined further using a non-hierarchical method – the k-means – which maximises the Euclidean distance between cluster centres while minimising the distance between members of any given cluster.
The model was refined further using CNS Solve (version 1.1), including simulated annealing, gradient minimization, individual occupancy, and refinement of individual isotropic temperature factors.
The models were refined further using CNS Solve (version 1.1), by simulated annealing, gradient minimization, individual occupancy, and refinement of the individual isotropic temperature factors.
Three different variations can then be followed in this method: the BLAST results can be used without further refinement, or they can be refined further by InterProScan using either family or subfamily classification.
We suspect that this method could be refined further, perhaps by using a longer plate, or stiffer material, or by improving plate attachment to the arm.
The questionnaires will be refined for further use in a larger study.
This definition can further be refined using basic, automated, routinely gathered laboratory data to help "the discriminatory power of risk models based on administrative data with abstracted diagnoses" [ 13].
These results could be refined still further by using the election commission's central computer.
A coarse rate control procedure is implemented using a constant within frame QP; such strategy can be further refined using a spatially varying QP as described in[14].
The existing model of the velocity structure at depth could then be further refined using our acoustic velocity and permeability data for reservoir rock matrix.
