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By contrast, islet TCF7L2 protein production has been suggested to be reduced in type 2 diabetes [ 9].
The elevation of circulating incretin concentrations is a desired effect in patients with type 2 diabetes, as it restores the incretin effect on β-cells that has been shown to be reduced in type 2 diabetes (48).
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Expression of Fbn1, Col1a1 and Col3a1 is reduced by type 1 diabetes in skeletal muscle [39], expression of these three genes as well as Col5a3, Col5a1 and Sparc is reduced by type 1 diabetes in corpus cavernosum [35], Sparc expression is reduced in type 1 diabetic kidneys [63], and Fbn1 and Col3a1 expression is reduced in type 1 diabetic heart muscle [38].
Among these cytokines, type I IFN and IL-6 are likely candidates as the number of CD8+ T cells is reduced in type I IFN- and IL-6-deficient mice [34], [35].
CV is reduced in type 2 diabetic ZDF rats.
In agreement, irisin in plasma is reduced in type 2 diabetes by 50% [ 28].
Statherin levels in parotid saliva (PS) were reduced in type 2 diabetics.
In the current study, we found that BMD is reduced in type 1 diabetes.
Plasma adiponectin levels are reduced in type 2 diabetes mellitus (T2DM) and other insulin-resistant states.
Peripheral insulin action is reduced in type 2 diabetics whereas AMPK signaling remains largely intact.
Bradykinin reduced oxygen consumption in normal dog heart in vitro and this was reduced in type I DM [ 12].
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