The difference of radiopharmaceutical structure between 11C-4DST and 18F-FLT (Figure 1A,B) is small; however, it has been recognized that small molecular changes of the chemical structure sometimes make greater difference in the pharmacokinetics of PET tracers.
While mouse and human AQP4 are 93% homologous, it is recognized that small differences in amino acid sequences, e.g. single residue substitutions, in heterologous proteins can have important effects on MHC binding as well as TCR-mediated stimulation [24], [25].
In any case, it has long been recognized that small deletions are more abundant than insertions of similar size in protein-coding sequences [ 46].
When making cross-sectional group comparisons, it must be recognized that our relatively small subject population (n = 4 7 subjects per group) combined with multiple comparisons could increase the potential of identifying spurious relationships.
It should also be recognized that there is a small but clinically important risk when administering these agents as their use has been associated with an increased risk for venous and arterial thrombosis [ 6- 10].
On the other hand, it must be recognized that the number of coarse particles is small (e.g., several orders of magnitude lower) compared with ultrafine particle counts (typically derived from nearby combustion sources) given similar overall mass concentrations of pollution (Brook et al. 2010).
While it has been recognized that even small islands can sustain endemic and endangered species of vertebrates, such forests are also important sites for endangered or even undiscovered species of plants, as further exploration of the remote islands of Lau will undoubtedly confirm.
First, it was recognized that certain small molecules could inhibit the activity of protein kinases [ 23].
Randomized trials of LC screening by chest radiography performed in the 1970s [ 9, 10] failed to answer the question of efficacy of radiographic screening, likely due to methodological flaws [ 11]; however, the possibility was recognized that a small but important benefit from annual CXR could have been missed [ 12- 14].
Subsequently it was recognized that even smaller increases in SCr (absolute increase in SCr ≥ 0.3 mg/dL) are associated with adverse outcome [ 42].
