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This suggests that genes within a distinct pathway have a specific epigenetic signature that allows them to be recognized by particular activating and/or repressing factors.
TFs that belong to the same structural family generally bind to similar sites (e.g., Figure 2 figure supplement 1 and Jolma et al., 2013), which is thought to represent the limited sequence space that can be recognized by particular protein folds.
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PSC is a rare disease that may not be recognized by a clinician without particular skills or awareness.
Although these effectors primarily function as virulence factors, specific effector molecules can also be recognized by plant R proteins in particular host genotypes resulting in activation of effector triggered immunity.
The mechanisms by which direct repeats may influence gene regulation are not completely understood but the formation of nonstandard DNA conformations, for example looping, which could either directly interfere with transcription or could be recognized by factors only present in particular cell types, have been proposed [54], [57], [58].
However, it is important to recognize that there could be differences of opinion regarding whether a particular phenotype could be recognized by a typical health care provider and/or specialist, and the phenotypic variability expected among newborns with a particular condition must be considered.
Thus, it is possible that a single paratope can bind two unrelated peptides (mimitopes), or a particular epitope can be recognized by two different paratopes with no sequence similarity.
Emerging data indicate that particular major histocompatibility complex (MHC -bound antigenic peptides can be recognized by identical or near-identical αβ T cell receptors (TCRs) in different individuals.
Although extremely rare, this particular form of lymphocytic mastitis, a diagnostic pitfall particulary during peroperative examination, should be recognized by pathologists.
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