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As an ABC transporter substrate, Epirubicin can be recognized and effluxed by multiple ABC transporters.
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Since retention of these fluorochromes in stem cells is impeded due to their rapid efflux, attributed primarily to MDR1 activity [ 11], stem cells can be recognized (and sorted out) as a distinct cell subpopulation characterized by much reduced fluorescence intensity.
Good teaching would be recognized and rewarded.
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We should be recognized and nurtured.
This needs to be recognized and addressed.
Being recognized and thanked is appreciated, too.
Go out and be recognized.
In phase III, the conjugated xenobiotics are recognized by efflux transporters and pumped out of cells [25].
One common mechanism of chemoresistance in cancer stem cells is due to ATP binding cassette (ABC) transporter proteins that are able to recognize and efflux drug molecules.
Our model drug Rhodamine 123 (Rh123) exhibits, like domperidone, a low brain permeability since both substances are recognized by efflux transporters at the BBB.
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