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Cisplatin-DNA adducts appear to be recognised by specific damage recognition proteins.
Until recently, there was a general assumption that imprints (ICRs, gDMRs) were specialised sequence elements that would be recognised by specific trans-acting factors that would target the de novo methylation machinery during gametogenesis.
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However, these appear to be produced once the parasite has entered the mammalian host, as they are recognised by specific antibodies in infected patients.
Therefore, MHC helices along with bound peptides, present a set of electrostatic charges that are recognised by specific TR domains.
When either Bax or Bak become activated, they undergo a conformational change, which reveals a neo-epitope that is recognised by specific antibodies.
In fact, poly(ADP-ribose) is recognised by specific chromatin-remodelling factors, but it can also directly affect chromatin compaction state [26 30].
In oocytes and early embryos of the African clawed frog, Xenopus, cytoplasmic polyadenylation can be conferred by several discrete elements in the 3′ untranslated region (3′ UTR) of the mRNA which are recognised by specific RNA binding proteins.
Indeed, mannoproteins are important C. albicans pathogen-associated molecular patterns (PAMPs) that are recognised by specific host pattern recognition receptors (PRRs) during host innate immune responses (Brown and Gordon, 2001; Gow et al., 2007; McKenzie et al., 2010; Netea et al., 2008, 2006; Sheth et al., 2011; Gow et al., 2012).
A potential candidate is the protein resilin which has the requisite elastic properties and can be recognised by the specific properties of its bright blue fluorescence when illuminated with particular wavelengths of UV light (see Methods).
The test's high specificity is based on the reaction to five different antigens, i.e. 110, 98, 95, 60/62, and 48 kDa proteins, which must be recognised by their specific antibodies in order to identify a positive serum [ 2].
The CS2 parasite line is recognised as being similar to placental-type isolates and known to bind to CSA and to be recognised by serum in a pregnancy-specific and gravidity-specific manner [25], [26].
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