These results suggest that the early pathogenesis of DMD can be recapitulated with our system utilizing hiPSCs.
Furthermore, inhibition of MEK with GDC-0973 can prevent this metabolic tumor resistance signaling, and this too is recapitulated with FDG-PET imaging.
This type of result is recapitulated with several pathways in the analysis.
Importantly, the respective phenotypes were recapitulated with multiple morpholinos and could be effectively rescued [ 15].
This behavioral effect could not be recapitulated in mice with reduced BDNF expression (Saarelainen et al. 2003), suggesting that BDNF signaling is necessary for the antidepressant effect.
Importantly, this particular phenotype could be recapitulated by stimulating monocytes with IFN-α [20].
The particles similarly diminished 3D collagen gel transwell invasion, again in a receptor-selective manner, effects which could be recapitulated in part by increasing concentrations of free hyaluronan.
Such mutations can be recapitulated in mice to generate animal models with direct etiological validity.
Indeed, impaired CHK1 phosphorylation was recapitulated after irradiating cells with 10 Gy X-rays (Supplementary Figure S3A), indicating that CHK1-signaling is compromised in PTEN-deficient cells.
