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From these experiments it is concluded that the salubrinal-mediated increase in PSI toxicity could be recapitulated by a second phosphatase inhibitor that supposedly targets PP1.
Interestingly, the opposite relationships can both be recapitulated by a simple model in which the natural environments of the organisms change frequently.
Such findings, taken together with the recognized complexity of natural ECM, make it seem unlikely that the functionality of ECM can be recapitulated by a limited set of synthetic or purified components.
Many of the binding properties of Smac can be recapitulated by a conserved tetrapeptide sequence, and small-molecule IAP antagonists that mimic the action of Smac have been designed to potentiate apoptosis in cancer cells [ 29– 329.
A new analysis published in BMC Biology suggests that this processive evolution down a single path can be recapitulated by a relatively simple model incorporating only two primary parameters - the mutation rate of the virus, and the immunological distance created by each mutation - so long as these parameters are within a particular narrow but biologically plausible range.
Thus, the mutagenic effects of repairing the various configurations of T/G, hmU/G and U/G shown in Figure 2A can be recapitulated by a given set of these lesions (i.e., 2 T/Gs, 2 hmU/Gs or 2 U/Gs at the same positions in the MM region, the uppermost bar graph of Figure 2 figure supplement 2).
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Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system.
D'Amato, NC, Ostrander, JH, Bowie, ML, Sistrunk, C, Borowsky, A, Cardiff, RD, Bell, K, Young, LJT, Simin, K, Bachelder, RE, Delrow, J, Dawson, A, Yee, LD, Mrózek, K, Clay, TM, Osada, T, and Seewaldt, VL. "Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system". PLoS One 7, no. 9 (2012): e45684-.
Furthermore, the proapoptotic effect of salubrinal occurred independently from the chemical nature of the proteasome inhibitor, was recapitulated by a second unrelated phosphatase inhibitor and was unaffected by overexpression of a dominant negative eIF2α S51A variant that can not be phosphorylated.
The global mechanism we identified here is recapitulated by a scheme, in Figure 7.
This experimental result was recapitulated by a mathematical model based on the delayed negative-feedback loop (Lewis, 2003; Monk, 2003).
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