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N-methylpyrrole/N-methylimidazole polyamides are molecules that can be rationally designed to target specific DNA sequences with exquisite precision.
Scaffolds in tissue engineering should be rationally designed to become an adhesion substrate friendly to cells.
They should be carefully chosen and preparation protocols should be rationally designed to maximize chances for success.
The scaffold can be rationally designed to modulate neotissue development to meet the needs of a specific application.
Pyrrole/imidazole-based polyamides can be rationally designed to target specific DNA sequences with exquisite precision in vitro; yet, the biological outcomes are often difficult to interpret using current models of binding energetics.
Recent work by our group has demonstrated that these organic salts can be rationally designed to stabilize proteins against thermal denaturation.
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The system is rationally designed to show life-like properties.
The protocols were rationally designed to best separate the mechanisms of permeabilization and electrophoretic transport.
Efficient sensors are rationally designed to diversify their applications in environmental science and engineering.
The nitro-chloromethylbenzindoline prodrug SN29428 has been rationally designed to target tumour hypoxia.
These drugs are rationally designed to target specific tyrosine kinases that are mutated and/or over-expressed in cancer tissues.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com