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(4) The heat capacity changes (Δ C p °) associated with the binding of the different SAHA analogues to HDAC8 cannot be rationalized in view of the classical hydrophobic binding model of the enzyme ligand complexes.
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Such a condition can be rationalized in two possible ways.
Stable isotope fractionation (e.g., D/H) can also be rationalized in this manner.
The enhancement of the degradation rate with addition of H2O2 can be rationalized in terms of several reasons.
(2) SAR transfer can be rationalized in different ways.
The effect of mutations affecting the enzymatic properties of AGT can be rationalized in structural terms.
So the unjust was rationalized in service of safe streets.
Such differences are rationalized in terms of polymer analyte interactions.
Ten DEPs were rationalized in a tumor-stroma co-evolution model, and associated with tumor metastasis.
The observed activity of the two variants with only one of either of the active site cysteines is easily rationalized in view of the fact that the escape mechanism is not necessary for the enzyme to function in assays with peptides, as described elsewhere (10).
The efficacy of IR in glioblastoma patients can, in part, be rationalized by this paradigm.
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