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The only partial restoring of the silencing activity of 9 and 12 may be rationalized considering that both the modified SS (no silencing) and the unmodified AS (silencing) occur.
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These results suggest that, without dismissing the importance of cellular mechanisms for controlling chromatin structure, very important details of the nucleosome organization around TSS and TTS can be rationalized considering physical properties of the naked DNA sequence.
This effect can be easily rationalized considering that in the latter condition, substrate binding to ADP-bound state becomes dominant and the system cannot exploit the time-scale separation in binding/unbinding kinetics to achieve ultra-affinity.
This result, apparently in contrast with what discussed above, can be rationalized by considering that Wenzel regime is thermodynamically advantaged, and that the nucleation condensation process does not pass through the CB-CB metastable configuration.
This difference can be rationalized by considering that ASE (peaked at 950 nm) is affected by self-absorption losses that are lower than those of the spontaneous emission (peak at ∼865 nm).
This can be rationalized with considering that most of the signal from O-H stretching vibrations is located above 3000 cm−1 in the IR spectra of LS4 glasses whereas it slightly extends toward lower frequency in the IR spectra of NS4 glasses (Le Losq et al. 2015b).
This difference can be rationalized by considering that NEDD1 and γ-Tubulin localize at the proximal and distal ends, respectively, of γTuRCs.
The differences between the two cell lines can be rationalized by considering that Δ40p53 may alter the dynamics of hetero-tetramers in two opposite ways.
These observations can be rationalized by considering that spiroindene formation requires the reductive elimination of RhIII from intermediates analogous to rhodacycle 7 (Scheme 2), with concomitant oxidation of the substrate.
This can be rationalized by considering that binding and release from ER chaperones is in competition with alternative fates (Sekijima et al., 2005), such as binding to export receptors like Tmp21.
These results were rationalized by considering that sulfonated 1-naphthylphosphanes are bulkier ligands than sulfonated 2-naphthylphosphanes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com