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Despite our best efforts, the preference for 3 vs. 4 (Table 1) cannot be rationalized at this point.
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Capital Expense (CAPEX) and inventory costs are predicted to be rationalized at 12 times and material, logistics & transportation costs expected to be rationalized at 11 times the rate of improvement since 1990.
The functions that require more coordination are statistically more error-prone and thus the link between variability and disease can be rationalized at mechanistic level.
Thus while the enhanced production of IFN-γ at 18 h post i.v. using the carbamate analogue of ThrCer can (at least in part) be rationalized by this CD1d agonist transactivating NK cells, in analogy to the behavior of the well-known Th1 cytokine-biasing analogue, 7, the cytokine profile observed for the thioamide analogue 11 cannot be attributed to this mechanism of IFN-γ production.
Stable isotope fractionation (e.g., D/H) can also be rationalized in this manner.
Increase in catalytic activity with increasing temperature could be rationalized that at higher temperature, phenyl ring of the borane moiety cannot bind with the active metal center which is beneficial for better activity.
It can be rationalized that mutation at position 336 also influences the positioning of substrate.
This can be rationalized by the fact that, at the molecular level, the interaction of CLR01 with Lys residues is based on the formation of inclusion complexes in which Lys is trapped inside the tweezer's cavity (Bier et al., 2013; Dutt et al., 2013).
These results show that the magnetic properties of nitronyl nitroxides cannot be rationalized by looking only at the relative orientations of the ONCNO groups, the spin containing groups in nitronyl nitroxides, as assumed up to now.
This might be rationalized by the availability of nitro group at carbon (4') for inter-molecular interactions.
This difference can be rationalized by considering that ASE (peaked at 950 nm) is affected by self-absorption losses that are lower than those of the spontaneous emission (peak at ∼865 nm).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com