Moreover, the phase information is rather subtle, and its consideration must be done with a great caution.
Our systematic investigation supports the previous findings, mainly based on the analysis of individual sequences, that the b-value of foreshocks is slightly lower than that of the aftershocks over a wide magnitude range of M3 7 (although the differences are rather subtle and, probably, still difficult to use for prospective earthquake forecasting).
However, these differences are rather subtle and somewhat subjective.
Aging is associated with a decline of testosterone levels; however, this physiological decline is rather subtle and is estimated to be -0.4% to -0.8% per year in cross-sectional studies [ 21, 22].
In our study, we were able to characterize in detail CB1R-induced actomyosin contraction, which is rather subtle and transitory downstream of endogenous GPCRs, by using high-resolution time-lapse imaging, atomic force microscopy, and moderate over-expression of CB1Rs.
Direct influence on the conformation, which is typically considered in the statistical (e.g., thermal equilibrium) approach, is rather subtle and is often described as a net effect mainly originating from a change of physicochemical characteristics of the solution (in the manner described by Anfinsen [ 24]) without resorting to an elaborate model yet; see, for example, [ 14, equation (3.164)].
Although under some conditions narrow-spiking presumed PV-positive neurons do respond at higher rates [5], in the auditory cortex the difference between PV-positive and PV-negative responsiveness can be rather subtle [43].
Even a qualitative or semi-quantitative assessment of these data require CAD tools to extract the information [ 7], detect and represent changes which might be rather subtle.
These results show that at least for the case of relatively short peptides, the interplay between thermodynamic stability and the apparent structural stability can be rather subtle, with even disordered regions contributing significantly to the stability of the folded state.
If such potential effects on learning and memory were to exist, these could be rather subtle and/or hidden by the vast environmental noise that envelops human intelligence.
Further, the majority of the yearly changes appear to be rather subtle, as only 5.4% of the temperature changes in our sample fall outside the interval [−1, 1] degree Celsius, and 1.65% of the changes in precipitation fall outside the interval [−5, 5] millimeters.
