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Participants will be randomly allocated to groups by concealed allocation.
Firstly, participants will be randomly allocated to intervention groups via concealed allocation.
Eligible patients will be randomly allocated to PPTR or LTR groups.
In the single subject randomized alternation design, any session can be randomly allocated to any treatment condition.
The trial will take place in 6 UK hospitals, and each centre will be randomly allocated to a transfusion policy.
All participating patients receive standard treatment by the general practitioner and will be randomly allocated to additional manipulative treatment.
Participants will be randomly allocated to intervention or control conditions.
120 eligible patients will be randomly allocated to three groups.
144 participants will be randomly allocated to either intervention.
Patients will be randomly allocated to PLDD or conventional surgery.
Patients will be randomly allocated to ACD, ACDF, or ACDP.
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